From the Research
Popular compounded topical scar gels in the USA typically include silicone-based formulations combined with other active ingredients for enhanced efficacy, as supported by recent studies such as 1. The most commonly prescribed compounded scar gels include combinations of silicone with tranilast (5-10%), tacrolimus (0.1%), triamcinolone (0.1-0.5%), and pentoxifylline (5%) 2. Another popular formulation is the "triple cream" which contains fluocinolone acetonide (0.01%), hydroquinone (4%), and tretinoin (0.05%) in a silicone base 3. These should be applied to clean, dry scars twice daily with gentle massage for 2-5 minutes, continuing treatment for at least 3-6 months for optimal results, as recommended by studies such as 4. Compounded scar gels work through multiple mechanisms:
- silicone creates occlusion and hydration
- corticosteroids reduce inflammation
- tacrolimus modulates immune response
- and ingredients like tranilast inhibit collagen production 5. These gels are particularly effective for hypertrophic scars and keloids but should be started early in the scar formation process, as suggested by 1. Patients should protect treated areas from sun exposure and discontinue use if irritation occurs, as advised by 2. These formulations require a prescription and are prepared by compounding pharmacies to address individual patient needs beyond what commercial over-the-counter products can provide, as noted in 3. It is essential to follow the treatment guidelines and recommendations from recent studies, such as 1, to ensure the best possible outcomes for patients with scars. Key considerations for treatment include:
- Early initiation of treatment
- Regular follow-up appointments
- Patient education on proper application and potential side effects
- Monitoring for signs of irritation or other adverse reactions, as recommended by 4. By prioritizing the most recent and highest-quality evidence, such as 1, healthcare providers can make informed decisions about the use of compounded topical scar gels in the USA.