From the Guidelines
The classic syphilis rash is typically described as a diffuse papulovesicular rash.
Key Characteristics
- The rash is generalized, meaning it appears on multiple parts of the body
- It has an acute onset, meaning it develops suddenly
- The rash is papulovesicular, meaning it consists of both papules (raised bumps) and vesicles (small blisters) As described in the case definitions for infectious conditions under public health surveillance by the Centers for Disease Control and Prevention 1, this type of rash is a key characteristic of syphilis and is often used in diagnosis.
From the Research
Description of a Classic Syphilis Rash
- A classic syphilis rash is typically described as a maculopapular rash that involves the palms and soles of the feet bilaterally 2
- The rash is often painless and can be accompanied by other symptoms such as headache, blurred vision, and neurological involvement 3, 4
- The rash can be diffuse and may spare the palms and soles in some cases, making diagnosis challenging 3, 5
- Dermoscopic clues can aid in the diagnosis of secondary syphilis, which is the stage of the disease characterized by the rash 6
- The rash can mimic other disease processes, making clinical examination and serological testing essential for diagnosis 2