What is the significance of weight gain during hemodialysis (HD)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 28, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Weight pull during dialysis should be managed by limiting sodium intake and performing adequate ultrafiltration to achieve a dry weight goal, with a recommended fluid removal rate not exceeding 10-13 ml/kg/hour, as evidenced by studies showing improved blood pressure control and reduced mortality rates 1.

Key Considerations

  • The amount of fluid removed during dialysis should be individualized based on the patient's cardiovascular status, residual kidney function, and tolerance to ultrafiltration.
  • Patients should maintain a consistent dry weight goal, which is the weight at which they have no signs of fluid overload but maintain adequate blood pressure.
  • To manage fluid between sessions, patients should limit sodium intake to 2-3 grams daily and restrict fluid intake to 1-1.5 liters per day.
  • Daily weight monitoring is crucial to track fluid status and report weight gains of more than 2-3 kg between sessions to their healthcare provider.

Rationale

The volume status of a maintenance dialysis patient is mainly a function of sodium intake, water intake, urine output, and removal of excess fluid by ultrafiltration during dialysis 1. Poor volume control can exacerbate hypertension and its detrimental effects on the cardiovascular system.

Management Strategies

  • Limiting sodium intake to 85-100 mmol/d and performing adequate ultrafiltration can decrease elevated blood pressures and improve hypertension substantially 1.
  • Alternative dialysis regimens, such as short-daily or long nocturnal regimens, can also remove excess fluid and improve hypertension satisfactorily 1.
  • Individualized fluid removal targets based on the patient's cardiovascular status, residual kidney function, and tolerance to ultrafiltration are essential for optimal dialysis outcomes.

Outcome

By managing weight pull during dialysis effectively, patients can achieve better control of blood pressure, regression of left ventricular hypertrophy, and improved overall outcomes, ultimately reducing morbidity, mortality, and improving quality of life 1.

From the Research

Weight Pull During Dialysis

  • Weight pull, also known as ultrafiltration, is a critical component of dialysis, as it helps remove excess fluid from the body 2.
  • The goal of ultrafiltration is to achieve a patient's "dry weight," which is the weight at which the body is free from excess fluid 2.
  • However, aggressive fluid removal during dialysis can lead to cardiovascular stress and potential organ damage 2.
  • A more precise approach to fluid management is required to improve cardiovascular outcomes in dialysis patients, taking into account factors such as fluid status assessment, cardiac biomarkers, and algorithm-based sodium modeling 2.

Factors Affecting Weight Pull

  • The use of diuretics, such as furosemide and metolazone, can help manage fluid overload in dialysis patients 3, 4, 5.
  • Combination therapy with low-dose metolazone and furosemide has been shown to be effective in managing refractory fluid overload in elderly renal failure patients under palliative care 3.
  • The dose and type of diuretic used can impact the effectiveness of fluid removal, and close monitoring is necessary to avoid complications such as ototoxicity and hyperkalemia 5.

Importance of Accurate Fluid Management

  • Fluid overload is a common complication in hemodialysis patients and can lead to increased incidence of hospitalization and mortality 6.
  • Accurate determination of fluid status is crucial to prevent fluid overload and its associated adverse outcomes 6.
  • Modern technology, such as biosensors and feedback control tools, may provide a more precise and personalized approach to fluid management in dialysis patients 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[Furosemide and metolazone: a highly effective diuretic combination].

Schweizerische medizinische Wochenschrift, 1980

Research

A review of diuretic use in dialysis patients.

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 2014

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.