From the Guidelines
The common SNRIs that are no longer available are not specified in the provided evidence, but currently marketed SNRIs in the United States include venlafaxine, desvenlafaxine, duloxetine, and levomilnacipran 1. When considering SNRIs, it's essential to note that the choice of medication may be governed by factors such as pharmacokinetics, pharmacodynamics, tolerability, cost, insurance formularies, and unique risks leading to warnings or precautions 1. Some key points to consider about currently available SNRIs include:
- Venlafaxine extended release, desvenlafaxine, and duloxetine have sufficiently long elimination half-lives to permit single daily dosing 1.
- Venlafaxine immediate release may require twice- or thrice-daily dosing due to its short elimination half-life 1.
- Duloxetine is the only SNRI with an FDA indication for the treatment of generalized anxiety disorder in children and adolescents 7 years old 1. If you have concerns about your SNRI medication, it's crucial to speak with your doctor about alternative options and to not abruptly stop taking your medication, as this can lead to discontinuation symptoms 1.
From the Research
Discontinued SNRIs
There are no research papers to assist in answering this question, as the provided studies do not mention any SNRIs that are no longer available.
Available Information on SNRIs
- The studies provided discuss the efficacy and adverse effects of various SNRIs, such as venlafaxine 2 and duloxetine 3.
- They also compare the effects of SNRIs with other types of antidepressants, like SSRIs 2, 3, 4, 5, 6.
- However, none of the studies mention any SNRIs that have been discontinued or are no longer available.