What are the guidelines for mailing insulin (intramuscular/intravenous hormone replacement therapy)?

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Last updated: May 28, 2025View editorial policy

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From the Guidelines

To mail insulin safely, it is crucial to maintain a refrigerated temperature between 36-46°F (2-8°C) using cold packs in an insulated container, as insulin is temperature-sensitive and requires specific conditions to maintain its quality 1. When shipping insulin, it is essential to use overnight or express delivery services that offer temperature-controlled options, such as FedEx Priority Overnight or UPS Next Day Air. Before shipping, check with the carrier about their policies for shipping medications and inform them that you're sending temperature-sensitive medication. Some key points to consider when mailing insulin include:

  • Package the insulin with multiple cold packs surrounded by bubble wrap or foam insulation, and place this inside a sturdy outer box.
  • Include clear "Temperature Sensitive" and "Medical Supplies" labels on the package.
  • Notify the recipient about the shipment so they can refrigerate the insulin immediately upon arrival. Proper temperature control is crucial because insulin proteins degrade when exposed to heat or freezing temperatures, which reduces effectiveness, as highlighted in recent expert recommendations 1. If possible, consult with a pharmacist before shipping to ensure the specific insulin type maintains stability during transit, considering the storage guidelines for insulin products vary by product and regional practices 1. It is also important to note that unopened insulin vials/pens should be stored in a refrigerator at 2 to 8 °C (36 to 46 °F), without freezing or contamination by food, and once opened, insulin vials/pens should be stored at ambient temperatures (15 to 30 °C or 59 to 86 °F) away from direct sunlight exposure until the expiration date designated by the manufacturer 1.

From the Research

Mailing Insulin

  • There are no specific studies on mailing insulin, but some studies provide information on the storage conditions of insulin, which can be relevant when mailing insulin 2.
  • Insulin should be stored at a temperature between 2°C and 8°C to maintain its potency 2.
  • When mailing insulin, it is essential to ensure that the insulin is not exposed to temperatures outside this range for an extended period.
  • Some studies have investigated the pharmacokinetic and metabolic effects of different types of insulin, such as insulin aspart and lispro 3, 4, 5, but these studies do not provide direct information on mailing insulin.
  • However, these studies suggest that the stability and potency of insulin can be affected by temperature and other environmental factors, which should be considered when mailing insulin.
  • It is crucial to follow proper packaging and shipping procedures to maintain the temperature and prevent damage to the insulin during transportation.
  • There is no direct evidence on the best way to mail insulin, but it is recommended to use insulated packaging, cold packs, and expedited shipping to ensure that the insulin is delivered quickly and at the correct temperature.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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