From the Guidelines
After stopping Crestor, most side effects typically resolve within 2 months, as indicated by the guideline that if, after 2 months without statin treatment, muscle symptoms or elevated CK levels do not resolve completely, consider other causes of muscle symptoms 1. The resolution of side effects after stopping Crestor (rosuvastatin) can vary depending on the specific side effect and individual factors.
- Common side effects like muscle pain, headaches, and digestive issues often improve within days to a couple of weeks.
- More severe side effects such as significant muscle damage (rhabdomyolysis) may take longer to resolve completely. It's essential to follow up with your healthcare provider if you've stopped Crestor due to side effects, as they may need to monitor your cholesterol levels and possibly recommend alternative treatments.
- Never stop taking Crestor without consulting your doctor first, as abruptly discontinuing statin therapy can potentially lead to cardiovascular events in high-risk patients, especially those with clinical ASCVD, diabetes, LDL-C ≥ 190 mg/dL, or level of estimated 10-year ASCVD risk 1. The half-life of Crestor is approximately 19 hours, meaning it takes about 4-5 days for the drug to be mostly eliminated from your body 1. However, the guideline suggests that if muscle symptoms resolve, and if no contraindication exists, give the patient the original or a lower dose of the same statin to establish a causal relationship between the muscle symptoms and statin therapy, and if a causal relationship exists, discontinue the original statin, and once muscle symptoms resolve, use a low dose of a different statin 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Side Effects of Crestor
The provided studies do not directly address how long it takes for side effects of Crestor (rosuvastatin) to go away after stopping the medication. However, they do discuss the side effects associated with rosuvastatin and their management.
Common Side Effects
- Myopathy and rhabdomyolysis are potential side effects of rosuvastatin, as with other statins 2
- Asymptomatic liver enzyme elevations occur with rosuvastatin at a similarly low incidence as with other statins 2
- Adverse effects related to the gastrointestinal tract and central nervous system have been reported 2
- Proteinuria induced by rosuvastatin is likely to be associated with a statin-provoked inhibition of low-molecular-weight protein reabsorption by the renal tubules 2
Management of Side Effects
- Co-enzyme Q10 supplementation has been suggested to reduce statin-induced myalgia 3, 4
- Low or intermittent dose rosuvastatin has been shown to be useful in lowering cholesterol with fewer side-effects 3
- Combination therapy with co-enzyme Q10 may have possible applications in ameliorating metabolic disorders 5
Duration of Side Effects
There is no direct evidence in the provided studies to determine how long it takes for side effects of Crestor to go away after stopping the medication. Further research would be needed to answer this question.