What is Charcot joint (neuropathic arthropathy)?

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Last updated: May 28, 2025 • View editorial policy

From the Guidelines

Treatment of a charqu joint, also known as a Charcot joint or neuropathic arthropathy, should focus on immobilization and offloading pressure, typically using a non-removable knee-high device, such as a total contact cast (TCC) or a prefabricated walker made non-removable, for 8-12 weeks, as recommended by the guidelines on the diagnosis and treatment of active Charcot neuro-osteoarthropathy in persons with diabetes mellitus (IWGDF 2023) 1, 2, 3, 4, 5, 6, 7.

Key Considerations

  • Immobilization and offloading are crucial to prevent further joint destruction and promote healing.
  • Non-weight bearing is recommended initially, with gradual return to protected weight bearing.
  • Pain management may include NSAIDs like ibuprofen (400-800mg three times daily) or acetaminophen (500-1000mg every 6 hours).
  • Surgical intervention is reserved for cases with severe instability or deformity that don't respond to conservative measures.

Diagnosis and Monitoring

  • Diagnosis is based on clinical signs of inflammation, such as increased temperature, edema, and redness, as well as signs of bone or joint injury/abnormalities on imaging studies like plain X-ray or MRI.
  • Regular monitoring with X-rays every 2-4 weeks during active disease is essential to track progression and adjust treatment accordingly.

Treatment Options

  • Total contact cast (TCC) is the preferred method of offloading, but a prefabricated knee-high walker made non-removable can be considered as a second choice.
  • Removable knee-high devices can be considered as a third treatment choice, but are less effective in immobilizing and offloading the foot.
  • Below-the-ankle devices are not recommended due to inadequate immobilization and offloading capacity.

Important Considerations

  • Treatment should be individualized based on patient factors, such as mobility, motivation, and socioeconomic status.
  • Healthcare professionals should have access to high-quality training and resources to provide optimal care for patients with charqu joint.
  • Patient education and shared decision-making are essential to ensure adherence to treatment and optimal outcomes.

From the Research

Charqu Joint

There is no direct information available on "charqu joint" in the provided studies.

  • The studies focus on rheumatoid arthritis, its treatment, and management, with discussions on disease-modifying antirheumatic drugs (DMARDs), biologic agents, and methotrexate 8, 9, 10, 11, 12.
  • They explore the use of methotrexate in combination with other DMARDs or biologic agents for treating rheumatoid arthritis, highlighting the importance of methotrexate as a first-line treatment 8, 10.
  • The studies also touch upon the potential side effects of these treatments, the need for monitoring, and considerations for dosage adjustments 9, 11.
  • However, none of the studies mention "charqu joint" specifically, suggesting that there may not be relevant research available on this topic within the provided evidence.

References

Research

Drug combinations with methotrexate to treat rheumatoid arthritis.

Clinical and experimental rheumatology, 2010

Research

Treatment of early rheumatoid arthritis: Methotrexate and beyond.

Current opinion in pharmacology, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.