From the Research
Aluminum chloride salts are the most effective topical treatment for hyperhidrosis, with Drysol (20% aluminum chloride hexahydrate) being the most commonly recommended prescription option. According to the most recent study 1, hyperhidrosis is a dermatosis presenting as pathologically excessive focal or generalized sweating, and conventional non-surgical treatments include aluminum salts, iontophoresis, botulinum toxin injections, and oral glycopyrronium.
Treatment Approach
The treatment approach for hyperhidrosis involves:
- Applying aluminum chloride salts to completely dry skin at bedtime, leaving on overnight, and washing off in the morning
- Starting with nightly applications until sweating decreases, then reducing to 1-2 times weekly for maintenance
- Covering treated areas with plastic wrap or wearing cotton gloves/socks if treating hands/feet for best results
- Using over-the-counter alternatives such as Certain Dri (12% aluminum chloride) or clinical-strength antiperspirants containing aluminum zirconium trichlorohydrex
Mechanism of Action
These salts work by forming plugs in sweat ducts and causing atrophy of secretory cells in sweat glands, as mentioned in the study 2.
Side Effects
Side effects may include skin irritation, burning, or itching, which can be minimized by ensuring skin is completely dry before application and using moisturizers during the day, as noted in the study 3. If skin irritation becomes severe, discontinue use and consult a healthcare provider about alternative treatments like prescription oral medications or procedures.
Alternative Treatments
Alternative treatments for hyperhidrosis include iontophoresis, botulinum toxin injections, and oral anticholinergics, as discussed in the study 4. However, aluminum chloride salts remain the most effective topical treatment option, with botulinum toxin showing significant improvement in palmar hyperhidrosis cases, as compared to iontophoresis and topical aluminum chloride hexahydrate, according to the study 5.