From the Research
Ozempic (semaglutide) should be stored in the refrigerator at 2°C to 8°C (36°F to 46°F) until first use, and after first use, it can be stored at room temperature (below 30°C or 86°F) for up to 56 days (8 weeks) to maintain its potency and effectiveness. When stored outside the refrigerator, Ozempic gradually degrades over time. The active ingredient, semaglutide, is a protein-based molecule that can break down when exposed to higher temperatures. This degradation process reduces the medication's potency and effectiveness.
Storage Recommendations
To ensure optimal efficacy:
- Keep unused pens refrigerated until needed.
- Once in use, store at room temperature away from direct heat and light.
- Discard the pen after 56 days, even if some medication remains.
- Never freeze Ozempic or expose it to temperatures above 30°C (86°F). The 56-day room temperature stability is based on the medication's formulation and extensive stability testing, as supported by the most recent study on medication storage temperatures 1. Beyond this period, the drug's potency cannot be guaranteed, potentially leading to reduced effectiveness in managing blood glucose levels.
Temperature Considerations
It is essential to note that storage temperatures outside the recommended range can affect the medication's stability, as observed in studies on temperature excursions for refrigerated medications 1. However, the specific stability of semaglutide at different temperatures is not directly addressed in the provided evidence. Therefore, adhering to the recommended storage conditions is crucial to maintain the medication's effectiveness.
Clinical Implications
In clinical practice, ensuring the proper storage of Ozempic is vital to maintain its efficacy in managing blood glucose levels. Healthcare providers should educate patients on the correct storage and handling of the medication to optimize its therapeutic benefits. By following the recommended storage guidelines, patients can help ensure that their medication remains potent and effective throughout its intended use period.