What is the cause of a rash and vomiting in a pediatric patient?

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Last updated: May 28, 2025 • View editorial policy

Differential Diagnosis for Rash and Vomiting in Pediatrics

Single Most Likely Diagnosis

  • Viral Gastroenteritis: This is the most common cause of rash and vomiting in pediatric patients, often accompanied by diarrhea and fever. The rash can be a result of the viral infection itself or a secondary reaction.

Other Likely Diagnoses

  • Food Allergy or Intolerance: An allergic reaction to food can cause vomiting, rash, and sometimes diarrhea. Common culprits include milk, eggs, peanuts, and shellfish.
  • Urinary Tract Infection (UTI): While more common in females, UTIs can cause vomiting and a rash in pediatric patients, especially if the infection has spread to the kidneys.
  • Viral Exanthems: Conditions like roseola, measles, and chickenpox can present with a rash and vomiting, often accompanied by fever and other systemic symptoms.

Do Not Miss Diagnoses

  • Meningitis: Although less common, meningitis is a life-threatening condition that can present with vomiting, rash (in the case of meningococcal meningitis), and signs of meningeal irritation.
  • Septicemia: Bacterial sepsis can cause a rash, vomiting, and severe systemic illness. Prompt recognition and treatment are crucial.
  • Kawasaki Disease: An acute febrile illness that can cause rash, vomiting, and other systemic symptoms. If untreated, it can lead to serious cardiac complications.

Rare Diagnoses

  • Stevens-Johnson Syndrome: A rare but serious condition usually triggered by medications or infections, characterized by a severe rash, blistering of the skin and mucous membranes, and systemic symptoms including vomiting.
  • Toxic Epidermal Necrolysis (TEN): Similar to Stevens-Johnson Syndrome but more severe, often requiring intensive care for management.
  • Erythema Multiforme: An immune-mediated condition that can cause a distinctive target-like rash and systemic symptoms, including vomiting, though it's less common in the context of vomiting compared to other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.