What is the comparison between Humacology (Cannabidiol) 0:110 CBD Isolate 'YELLOW' Pastilles and Humacology (Cannabidiol + Cannabinol + Cannabichromene) 0:250:60:20 Broad Spectrum CBD (Cannabidiol) + CBN (Cannabinol) + CBC (Cannabichromene) Oil?

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Last updated: May 28, 2025View editorial policy

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From the Guidelines

For most users, I recommend the Humacology "BLACK" 0:250:60:20 Broad Spectrum CBD+CBN+CBC Oil over the Humacology 0:110 CBD Isolate "YELLOW" Pastilles, as it contains a higher CBD concentration and additional cannabinoids that may enhance therapeutic benefits through the "entourage effect" 1. The broad spectrum formulation in the BLACK oil preserves multiple cannabis compounds while removing THC, offering more comprehensive effects than the CBD isolate in the YELLOW pastilles.

When considering the choice between these two products, several key factors come into play:

  • The CBD concentration: The BLACK oil contains 250mg of CBD, compared to 110mg in the YELLOW pastilles.
  • The presence of additional cannabinoids: The BLACK oil includes CBN and CBC, which may work together with CBD to enhance therapeutic benefits.
  • The formulation: The broad spectrum formulation in the BLACK oil preserves multiple cannabis compounds, while the YELLOW pastilles contain only pure CBD.
  • The format: The oil format allows for flexible dosing and faster absorption under the tongue, while pastilles provide consistent pre-measured doses and may be more convenient for on-the-go use.

It's also important to consider the potential risks and benefits of cannabis and cannabinoid use, as outlined in the studies 1. These studies highlight the importance of careful consideration and monitoring when using cannabis and cannabinoid products, particularly in certain populations such as those with cancer or those undergoing surgery.

Ultimately, the choice between the Humacology "BLACK" 0:250:60:20 Broad Spectrum CBD+CBN+CBC Oil and the Humacology 0:110 CBD Isolate "YELLOW" Pastilles will depend on individual needs and preferences. However, based on the available evidence, the BLACK oil is likely to be a better choice for those seeking potentially stronger effects and benefits from multiple cannabinoids.

From the Research

Comparison of Humacology Products

  • The Humacology 0:110 CBD Isolate "YELLOW" Pastilles and Humacology "BLACK" 0:250:60:20 Broad Spectrum CBD+CBN+CBC Oil differ in their composition and potential effects.
  • The CBD Isolate Pastilles contain only CBD, whereas the Broad Spectrum Oil contains a combination of CBD, CBN, and CBC.

Effects of CBD and Minor Cannabinoids

  • Studies have shown that CBD can improve sleep quality 2 and has anti-inflammatory properties 3, 4.
  • The addition of minor cannabinoids such as CBN and CBC may not improve the effect of CBD isolate on sleep quality 2.
  • However, the combination of CBD and CBC has been shown to have a greater anti-inflammatory effect than either minor cannabinoid alone 3.

Mechanism of Action

  • CBD has been shown to interact with TRP channels and enzymes of the endocannabinoid system 4.
  • The combination of CBD and other cannabinoids may have synergistic effects, leading to increased efficacy 5.

Potential Benefits and Drawbacks

  • The Broad Spectrum Oil may have a more pronounced effect due to the combination of cannabinoids, but this has not been directly studied.
  • The CBD Isolate Pastilles may be more suitable for individuals who prefer a single-ingredient product or have sensitivity to other cannabinoids.
  • Further research is needed to fully understand the effects and interactions of these products.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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