From the Guidelines
I strongly advise against combining "BLACK" 0:250:60:20 Broad Spectrum CBD+CBN+CB products with Effexor 37.5mg without medical supervision due to potential drug interactions. CBD can inhibit the cytochrome P450 enzyme system in the liver, which metabolizes many medications including venlafaxine (Effexor) 1. This interaction could potentially increase Effexor levels in your bloodstream, leading to enhanced side effects or toxicity. Additionally, both substances can affect serotonin levels, potentially increasing the risk of serotonin syndrome, a serious condition characterized by agitation, hallucinations, rapid heart rate, fever, excessive sweating, shivering, muscle stiffness, and seizures 1. If you're considering using CBD products while on Effexor, consult your healthcare provider first. They may recommend starting with a very low dose of CBD and monitoring for side effects, or they might suggest adjusting your Effexor dosage 1. Some key points to consider when taking CBD with Effexor include:
- Starting with a low dose of CBD and gradually increasing as needed and under medical supervision
- Monitoring for signs of serotonin syndrome, such as agitation, hallucinations, and rapid heart rate
- Being aware of the potential for increased Effexor levels in the bloodstream and associated side effects
- Consulting with a healthcare provider before making any changes to your medication regimen Never make changes to your prescribed medication regimen without professional guidance.
From the Research
Interaction between CBD, CBN, CBG, and Effexor
- There is limited research on the interaction between Broad Spectrum CBD+CBN+CBG and Effexor 37.5mg 2, 3, 4, 5.
- Studies suggest that CBD and CBG may have therapeutic potential in treating various disorders, including neurologic disorders and inflammatory bowel disease 2, 3.
- CBG exhibits affinity and activity characteristics between Δ9-THC and CBD at the cannabinoid receptors, but appears to be unique in its interactions with α-2 adrenoceptors and 5-hydroxytryptamine (5-HT1A) 2.
- The pharmacological effects of CBG include reducing intraocular pressure, possessing antioxidant, anti-inflammatory, and anti-tumoral activities, and having anti-anxiety, neuroprotective, dermatological, and appetite-stimulating effects 3.
Neuroprotective Effects
- A comparative in vitro study found that CBD and CBG induce neuroprotective effects on toxic and neurodegenerative processes, with CBG showing a more significant effect against rotenone-induced neurotoxicity 5.
- The study also found that the 5-HT1A receptor antagonist WAY100635 significantly diminished the neuroprotective effect induced by CBG, highlighting the role of 5-HT1A receptors in the mechanisms of action of CBG 5.
Cardiovascular Risks
- A study on Janus kinase inhibitors found that there is considerable controversy related to the cardiovascular safety of these inhibitors, with an increased risk of major adverse cardiovascular events (MACE), venous thromboembolism (VTE), and malignancy 6.
- However, this study is not directly related to the interaction between CBD, CBN, CBG, and Effexor, and more research is needed to understand the potential cardiovascular risks associated with this combination 6.