From the Research
Trintellix (vortioxetine) is not currently available as a generic medication in the United States, but it may be available in some countries. In the US, vortioxetine remains under patent protection by Takeda Pharmaceuticals until 2026, meaning no FDA-approved generic version exists yet 1. Trintellix is an atypical antidepressant that works as a serotonin modulator and stimulator, treating major depressive disorder by affecting serotonin receptors in multiple ways. It comes in 5mg, 10mg, and 20mg tablets, with typical starting doses of 10mg once daily, potentially increasing to 20mg daily based on response. When generic vortioxetine eventually becomes available, it should contain the same active ingredient and work similarly to the brand-name version, though inactive ingredients may differ slightly. Some studies suggest that vortioxetine may have neuroprotective effects, particularly in the treatment of anxiety disorders, as evidenced by a meta-analysis study published in 2018 1. However, the current evidence is limited, and further long-term studies are needed to fully understand the effects of vortioxetine on anxiety disorders. Patients currently taking Trintellix should continue their prescribed medication and consult their healthcare provider about future generic options, as switching between brand and generic medications sometimes requires dosage adjustments. Key points to consider when prescribing or taking Trintellix include:
- Starting dose: 10mg once daily
- Potential increase to 20mg daily based on response
- Availability of generic version: currently not available in the US, but may be available in some countries
- Potential neuroprotective effects: evidenced by some studies, but further research is needed
- Importance of consulting a healthcare provider: before switching to a generic version or adjusting dosage.