What is the recommended dosing frequency for Synjardy (Empagliflozin and Metformin)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the FDA Drug Label

2.1 Recommended Dosage The recommended dose of JARDIANCE is 10 mg once daily in the morning, taken with or without food.

The dose of Synjardy (which contains empagliflozin) is not directly stated in the provided label, as the label is for JARDIANCE (empagliflozin). However, Synjardy is a combination of empagliflozin and metformin.

  • The recommended dose of JARDIANCE (empagliflozin) is 10 mg once daily in the morning, taken with or without food 1. Since the provided label does not directly address Synjardy, no conclusion can be drawn about the dosing of Synjardy.

From the Research

Synjardy should be taken twice daily with meals, usually once in the morning and once in the evening, to minimize gastrointestinal side effects and maintain stable blood glucose levels throughout the day and night. The standard dosing regimen involves taking one tablet containing empagliflozin and metformin hydrochloride at the start of each meal.

  • The specific dosage strength depends on your doctor's prescription, which is based on your blood sugar levels, kidney function, and previous diabetes medication history 2.
  • It's essential to take Synjardy consistently at the same times each day to maintain stable blood glucose levels throughout the day and night.
  • Never skip doses or double up on missed doses without consulting your healthcare provider.
  • Taking Synjardy with food is recommended not only to reduce stomach upset but also because the medication works in conjunction with your meals to help control post-meal blood sugar spikes.
  • If you miss a dose, take it as soon as you remember unless it's almost time for your next dose, in which case skip the missed dose and continue with your regular schedule. The most recent study 3 suggests that weight gain is associated with worsening glycemia and increased risk of cardiovascular and kidney outcomes, which further emphasizes the importance of taking Synjardy as prescribed to maintain optimal blood glucose control and minimize potential complications.

Related Questions

Can a patient with type 2 diabetes take metformin together with Jardiance (empagliflozin) and glipizide?
What are the next steps in managing diabetes for a patient taking empagliflozin and metformin with intolerance to Ozempic and insulin, and grossly overweight?
How to adjust insulin glargine (Lantus) and carbohydrate ratio when adding metformin (Glucophage) and empagliflozin (Jardiance) to a patient's regimen?
What adjustments should be made to the treatment plan for a patient with hyperglycemia, currently taking Jardiance (Empagliflozin) 25mg and Janumet (Sitagliptin/Metformin) 50-1000mg?
What are the considerations for starting Synjardy XL (empagliflozin and metformin) in an elderly female patient with type 2 diabetes mellitus, currently taking glipiZIDE (glyburide) 10 MG Tablet, Januvia (sitagliptin) 50 MG Tablet, and Lantus (insulin glargine) at night, with blood glucose levels ranging from mild hyperglycemia to moderate hyperglycemia?
What is the definition of Sick Sinus Syndrome (SSS)?
What does a Pap smear result of negative for intraepithelial lesion or malignancy with a predominance of coccobacilli consistent with a shift in vaginal flora indicate?
What rate control medication can be added to amiodarone (antiarrhythmic) and metoprolol (beta blocker)?
What are the implications of gout with normal uric acid levels?
What is the diagnosis for a patient with gout and normal serum uric acid levels?
What is the inotrope of choice in right ventricular (RV) infarction with cardiogenic shock after fluid resuscitation?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.