From the Guidelines
Juven does not have a direct role in managing bleeding, and its use is not supported by the provided evidence as a treatment for bleeding. Instead, the management of bleeding, particularly in patients on oral anticoagulants, involves assessing the severity of the bleed and implementing appropriate strategies such as stopping the anticoagulant, administering reversal agents like vitamin K or prothrombin complex concentrates, and providing supportive care 1. For patients on vitamin K antagonists (VKAs) with major bleeding, the administration of 5-10 mg IV vitamin K is recommended, along with other supportive measures 1. In cases of life-threatening bleeding, more aggressive interventions may be necessary, including the use of recombinant activated factor VII, although its use is not widely recommended due to the risk of thrombosis 1. Key considerations in managing bleeding include:
- Assessing the severity of the bleed and the patient's hemodynamic stability
- Stopping the oral anticoagulant and any antiplatelet agents
- Administering reversal agents as appropriate (e.g., vitamin K for VKAs)
- Providing local therapy and supportive care
- Considering surgical or procedural management of the bleeding site if necessary The most recent and highest quality evidence supports a tailored approach to bleeding management, taking into account the specific anticoagulant used, the severity of the bleed, and the patient's overall clinical condition 1.
From the Research
Juven and Bleeding
- There is no direct information available on what Juven does for bleeding.
- However, the provided studies discuss the role of vitamin C in preventing and treating bleeding disorders, such as scurvy 2, 3, 4.
- Scurvy is a nutritional disorder caused by prolonged vitamin C deficiency, which can lead to blood vessel fragility, poor wound healing, and mucocutaneous bleeding 3.
- Vitamin C supplementation has been shown to rapidly resolve symptoms of scurvy, including bleeding 3, 5.
- The daily recommended intake of vitamin C is approximately 60 mg, which can be found in foods such as oranges 3.
- Risk factors for scurvy development include undernutrition, low socioeconomic status, older age, male sex, alcoholism, tobacco smoking, and severe psychiatric illnesses 3.
- It is essential for clinicians to be aware of the nutritional status of patients and the possibility of vitamin C deficiency, which may hinder wound healing and cause bleeding 6.