From the Research
NAD+ supplementation may help improve insulin sensitivity and metabolic function in diabetics, but it is not yet a proven treatment and should be used with caution under medical supervision. The most recent and highest quality study on this topic is a systematic review published in 2024, which found that NAD+ supplementation was well-tolerated and associated with improved clinical outcomes, including increased muscle insulin sensitivity and improved quality of life 1. However, the study also noted that NAD+ supplementation may have side effects, such as muscle pain, nervous disorders, and headaches, and that further research is needed to confirm its clinical benefits.
Key Points to Consider
- NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in cellular energy production and plays a role in regulating glucose metabolism.
- As people age or develop metabolic disorders like diabetes, NAD+ levels naturally decline.
- Supplements like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) can boost NAD+ levels, with typical doses ranging from 250-1000mg daily.
- While some studies suggest that NAD+ may help improve insulin sensitivity and metabolic function, the research is still emerging and diabetics should consult their healthcare provider before starting any supplement regimen.
- Other supplements, such as alpha-lipoic acid, may also have beneficial effects on metabolic syndrome and insulin sensitivity, but more research is needed to confirm their clinical efficacy 2, 3.
Important Considerations for Diabetics
- NAD+ supplementation should complement, not replace, standard diabetes treatments such as metformin, insulin, or other prescribed medications.
- Diabetics should consult their healthcare provider before starting any supplement regimen, especially since NAD+ boosters may interact with existing medications or affect blood sugar levels in unpredictable ways.
- Regular monitoring of blood sugar levels and other health parameters is crucial when using NAD+ supplementation or any other complementary therapy.