From the Guidelines
Teduglutide is the most effective peptide for improving Functional Quality (FQ) of life, particularly in patients with short bowel syndrome, due to its intestinotrophic effects and ability to enhance intestinal absorptive function, as evidenced by the 2022 study published in Clinical Gastroenterology and Hepatology 1. The advantages of taking peptides like teduglutide include:
- Improved intestinal absorptive function
- Potential to wean off parenteral nutrition
- Enhanced growth of intestinal tissue
- Possible improvement in quality of life However, there are also disadvantages to consider:
- Significant side effects, such as the potential to accelerate cancer growth
- Contraindication in patients with active gastrointestinal malignancies
- High cost and limited availability
- Need for careful patient selection and monitoring In terms of recommended regimen, teduglutide should be administered via daily subcutaneous injection, with careful consideration of the potential benefits and risks, as well as regular screening for gastrointestinal malignancies 1. It is essential to note that the use of peptides like teduglutide should be approached with caution, and patients should be thoroughly informed of the potential benefits and risks associated with growth factor treatments. Additionally, the decision to continue teduglutide in patients with nongastrointestinal malignancy should be made based on benefit-risk considerations, and it is recommended to avoid its use in patients with active or recent malignancy, irrespective of location 1.
From the Research
Advantages of Peptides
- Bioactive peptides can have a positive effect on health-related parameters such as hypertension, dyslipoproteinemia, inflammation, and oxidative stress 2
- Bioactive peptides could have a positive impact on changes in body composition and muscular performance, reduce muscle damage following exercise, and induce beneficial adaptions within the connective tissue 2
- Food-derived bioactive peptides can reduce muscle damage following exercise and induce beneficial adaptions within the connective tissue 3
- Self-assembling peptide hydrogels can enhance peripheral nerve regeneration 4
Disadvantages of Peptides
- Substituting a portion of whey protein for collagen peptide may not improve indices of eccentric muscle damage or functional outcomes during eccentric training 5
- The complexity of the histoarchitectural considerations for skeletal muscle injuries and the repair mechanism of damaged skeletal muscle are not well known 3
- Peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics 6
Effective Peptides for Functional Quality (FQ) of Life
- Collagen peptides may enhance muscular recovery and function when combined with resistance exercise 5
- Bioactive peptides can be resorbed in their intact form and have a positive effect on health-related parameters 2
- Food-derived bioactive peptides can reduce muscle damage following exercise and induce beneficial adaptions within the connective tissue 3
- Self-assembling peptide hydrogels functionalized with LN- and BDNF-mimicking epitopes can synergistically enhance peripheral nerve regeneration 4