What is the differential diagnosis for ulcers on the lateral tongue and buccal mucosa?

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Last updated: May 29, 2025 • View editorial policy

Differential Diagnosis for Mouth Sores on Side of Tongue and Inner Cheeks

Single Most Likely Diagnosis

  • Recurrent Aphthous Stomatitis (Canker Sores): This is the most common cause of mouth sores, characterized by painful, shallow ulcers on the inner cheeks, lips, and tongue. The condition is often recurrent and can be triggered by stress, minor mouth injury, or certain foods.

Other Likely Diagnoses

  • Oral Lichen Planus: An autoimmune condition that can cause white, lacy patches or painful sores on the inner cheeks, tongue, and gums.
  • Traumatic Ulcers: Mouth sores caused by accidental bites, dental work, or other minor injuries to the mouth.
  • Herpes Simplex Virus (HSV) Infection: Although more commonly associated with cold sores on the lips, HSV can also cause sores on the inner cheeks and tongue.
  • Nutritional Deficiencies: Deficiencies in vitamins such as B12, iron, or folate can lead to mouth sores and other oral health issues.

Do Not Miss Diagnoses

  • Oral Cancer: Although less common, mouth sores that do not heal can be a sign of oral cancer, making it crucial to rule out this diagnosis, especially in patients with risk factors such as tobacco use or a history of radiation therapy.
  • Syphilis: Secondary syphilis can cause mouth sores, among other symptoms, and is essential to diagnose due to its potential for serious complications if left untreated.
  • HIV/AIDS: Individuals with HIV/AIDS are more prone to oral health issues, including mouth sores, due to their compromised immune system.

Rare Diagnoses

  • Pemphigus Vulgaris: A rare autoimmune disease that causes blistering of the skin and mucous membranes, including the mouth.
  • Erythema Multiforme: A rare skin condition that can also affect the mucous membranes, leading to mouth sores and other symptoms.
  • Behçet's Disease: A rare disorder that causes inflammation throughout the body, including the mouth, leading to sores and other oral health issues.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.