Reconstitution of Solu-Cortef 100 mg
For a 100 mg vial of Solu-Cortef (hydrocortisone sodium succinate), add not more than 2 mL of bacteriostatic water for injection. 1
Reconstitution Instructions
The FDA-approved drug label provides explicit reconstitution guidance for the 100 mg plain vial:
- Add not more than 2 mL of Bacteriostatic Water for Injection (or Bacteriostatic Sodium Chloride Injection) to the contents of one 100 mg vial 1
- Use aseptic technique when adding the diluent
- The resulting solution can be used for either intramuscular or intravenous injection
Important Technical Considerations
Sterile technique is essential. The reconstituted solution should be used immediately from a microbiological standpoint unless the method of reconstitution precludes microbial contamination 1. If not used immediately, storage times and conditions become the responsibility of the user.
Heat sensitivity: This product is sensitive to heat and should not be autoclaved when sterilizing the exterior of the vial 1.
For Further Dilution
If preparing for intravenous infusion after initial reconstitution with 2 mL:
- The reconstituted 100 mg solution may then be added to 100-1000 mL of 5% dextrose in water, isotonic saline, or 5% dextrose in isotonic saline 1
- For small volume administration, 100 mg can be added to as little as 50 mL of diluent
- These solutions remain stable for at least 4 hours 1
The pH of properly reconstituted solutions ranges from 7 to 8 1.