Differential Diagnosis for Swelling of the Hands and Feet
Single Most Likely Diagnosis
- Idiopathic Edema: This is a common condition characterized by swelling in the hands and feet without an identifiable cause. It is often seen in women and can be related to hormonal changes.
Other Likely Diagnoses
- Hypothyroidism: Swelling in the hands and feet can be a symptom of hypothyroidism due to the accumulation of mucopolysaccharides in the skin.
- Renal Disease: Conditions such as nephrotic syndrome can cause edema due to protein loss and decreased oncotic pressure.
- Heart Failure: Right-sided heart failure can lead to peripheral edema, including swelling in the hands and feet.
- Lymphedema: A condition characterized by the abnormal accumulation of protein-rich fluid in the interstitial tissue, leading to swelling.
Do Not Miss Diagnoses
- Deep Vein Thrombosis (DVT): Although less common, DVT can cause swelling in one leg or arm and is a medical emergency due to the risk of pulmonary embolism.
- Sepsis: Severe infections can cause edema as part of a systemic inflammatory response, which can be life-threatening if not promptly treated.
- Superior Vena Cava Syndrome: Obstruction of the superior vena cava can cause swelling in the arms and face, which is a medical emergency.
Rare Diagnoses
- Scleroderma: A chronic autoimmune disease that can cause swelling and thickening of the skin in the hands and feet.
- Erythromelalgia: A rare disorder characterized by burning pain, heat, and swelling in the hands and feet.
- Klippel-Trenaunay Syndrome: A rare congenital condition that can cause swelling and malformations in the limbs due to abnormal blood and lymphatic vessels.