From the Guidelines
Naproxen should be dosed at 275-550 mg every 2-6 hours, with a maximum daily dose of 1.5 g, as recommended by the most recent and highest quality study 1.
Naproxen Dosing Considerations
When considering naproxen dosing, it is essential to take into account the patient's individual needs and medical history.
- For adults, the typical dosing range is 275-550 mg every 2-6 hours, with a maximum daily dose of 1.5 g.
- For elderly patients or those with renal impairment, lower doses are recommended to minimize the risk of adverse effects.
- Naproxen should be taken with food to reduce gastrointestinal side effects.
Mechanism of Action and Side Effects
As a non-steroidal anti-inflammatory drug (NSAID), naproxen works by inhibiting cyclooxygenase enzymes to reduce inflammation and pain.
- Patients should be aware of potential side effects, including stomach upset, heartburn, and increased risk of cardiovascular events with prolonged use.
- Those with a history of heart disease, kidney problems, or gastrointestinal bleeding should consult their healthcare provider before taking naproxen, as recommended by 1 and 1.
Comparison with Other Studies
While other studies, such as 1, provide information on naproxen dosing, the most recent and highest quality study 1 takes precedence in guiding clinical decision-making.
- The study published in 2022 1 provides the most up-to-date recommendations for naproxen dosing, emphasizing the importance of using the lowest effective dosage and shortest duration needed to minimize risks.
From the FDA Drug Label
The recommended dose is 250 mg, 375 mg, or 500 mg twice daily The recommended starting dose of naproxen is 500 mg, followed by 500 mg every 12 hours or 250 mg every 6 to 8 hours as required. The initial total daily dose should not exceed 1250 mg of naproxen. Thereafter, the total daily dose should not exceed 1000 mg of naproxen. The recommended total daily dose of naproxen is approximately 10 mg/kg given in 2 divided doses (i.e., 5 mg/kg given twice a day). The recommended starting dose is 750 mg of naproxen followed by 250 mg every 8 hours until the attack has subsided.
The recommended dosing of naproxen varies by indication:
- Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis: 250 mg, 375 mg, or 500 mg twice daily
- Management of Pain, Primary Dysmenorrhea, and Acute Tendonitis and Bursitis: 500 mg, followed by 500 mg every 12 hours or 250 mg every 6 to 8 hours as required
- Juvenile Arthritis: approximately 10 mg/kg given in 2 divided doses
- Acute Gout: 750 mg followed by 250 mg every 8 hours until the attack has subsided 2