From the Research
Sermorelin is typically dosed at 100-500 mcg injected subcutaneously once daily, usually before bedtime, with the most recent and highest quality study 1 suggesting its potential effectiveness in various conditions, including recurrent glioma. For most adults seeking growth hormone optimization, starting at 200-300 mcg daily is common, with adjustments made based on response. The timing before sleep is important as it aligns with the body's natural growth hormone pulse patterns. A typical treatment course lasts 3-6 months initially, though some patients may continue longer-term therapy under medical supervision. Some key points to consider when administering sermorelin include:
- Side effects are generally mild and may include injection site reactions, headache, or flushing.
- Sermorelin works by stimulating the pituitary gland to produce more natural growth hormone rather than directly replacing it, which helps maintain the body's normal feedback mechanisms.
- This approach may reduce risks associated with direct growth hormone administration.
- Blood tests to monitor IGF-1 levels are recommended every 3-6 months during treatment to ensure appropriate dosing.
- Always use proper injection technique with alcohol swabs and rotate injection sites to minimize local reactions.
- Sermorelin requires refrigeration after reconstitution and typically remains stable for about 30 days when properly stored. It's essential to note that while sermorelin has shown promise in various studies, including one from 2021 1, its use should be guided by the most recent and highest quality evidence, and patients should be closely monitored for any adverse effects or changes in their condition.