What is the cause of postprandial nausea in a 27-year-old female, 3 months postpartum, with no vomiting or other symptoms, and a normal abdominal examination (Abd) and no adenopathy (NAD)?

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Last updated: May 30, 2025 • View editorial policy

Differential Diagnosis for 27-year-old Female with Postpartum Nausea

Single most likely diagnosis

  • Gastroesophageal Reflux Disease (GERD): This condition is common in postpartum women due to hormonal changes and increased intra-abdominal pressure during pregnancy. The symptoms of nausea after meals without vomiting are consistent with GERD.

Other Likely diagnoses

  • Functional Dyspepsia: This is a common condition characterized by recurrent upper abdominal symptoms, including nausea, without an identifiable cause. The postpartum period can exacerbate symptoms due to stress and hormonal changes.
  • Irritable Bowel Syndrome (IBS): Although IBS typically presents with abdominal pain and changes in bowel habits, some patients may experience nausea, especially after meals. The postpartum period can trigger or worsen IBS symptoms.
  • Postpartum Thyroiditis: This condition can cause nausea, among other symptoms, due to thyroid hormone fluctuations. It is more common in the postpartum period.

Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)

  • Pulmonary Embolism: Although less common, pulmonary embolism can present with nausea and is a life-threatening condition that requires immediate attention. The postpartum period increases the risk of thromboembolic events.
  • Postpartum Preeclampsia: This condition can occur after delivery and may present with nausea, among other symptoms. It is a serious condition that requires prompt medical attention.
  • Gallbladder Disease: Gallstones or cholecystitis can cause nausea after meals, and the postpartum period is a risk factor for gallstone formation.

Rare diagnoses

  • Gastric Cancer: Although rare in young women, gastric cancer can present with nausea and should be considered if other symptoms or risk factors are present.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis can cause nausea, among other symptoms, and may be triggered or worsened by the postpartum period.
  • Adrenal Insufficiency: This rare condition can cause nausea and is more common in the postpartum period, especially in women with a history of adrenal disease.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.