What malignancies are associated with exposure to Agent Orange (Dioxin)?

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Last updated: May 30, 2025View editorial policy

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From the Research

Agent Orange exposure is associated with several malignancies, including chronic B-cell leukemias, Hodgkin's disease, multiple myeloma, non-Hodgkin's lymphoma, prostate cancer, respiratory cancers, and soft tissue sarcomas, as well as acute myeloid leukemia and myelodysplastic syndrome, as supported by the most recent study 1.

Malignancies Associated with Agent Orange Exposure

The following malignancies have been linked to Agent Orange exposure:

  • Chronic B-cell leukemias
  • Hodgkin's disease
  • Multiple myeloma
  • Non-Hodgkin's lymphoma
  • Prostate cancer
  • Respiratory cancers (including lung, bronchus, larynx, and trachea)
  • Soft tissue sarcomas
  • Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) 1

Evidence Supporting the Association

Studies have consistently shown that Agent Orange exposure increases the risk of developing these malignancies, with the most recent study published in 2022 1 providing strong evidence for the association between Agent Orange exposure and AML/MDS.

Importance of Medical Surveillance

Veterans exposed to Agent Orange during military service, particularly in Vietnam between 1962 and 1975, may be eligible for VA disability benefits if diagnosed with these conditions, and ongoing medical surveillance is crucial for those with known exposure, as the latency period between exposure and cancer development can be decades 2, 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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