Does octyl salicylate (octisalate) cause cancer?

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Last updated: May 30, 2025 • View editorial policy

From the Research

Octisalate has not been shown to cause cancer in humans, and its use in sunscreens is considered safe for cancer prevention when used as directed. Octisalate, also known as ethylhexyl salicylate, is a common ingredient in sunscreens and other cosmetic products that functions as a UV filter, absorbing harmful UVB rays to protect the skin from sun damage 1. The ingredient has been extensively tested and is approved by regulatory agencies like the FDA for use in sunscreen products at concentrations up to 5%. While some concerns have been raised about certain chemical sunscreen ingredients being absorbed into the bloodstream, there is no evidence linking octisalate specifically to cancer development.

Some key points to consider:

  • Octisalate is used in combination with other UV filters, such as oxybenzone and avobenzone, to provide broad-spectrum protection against UVA and UVB radiation 1.
  • The use of sunscreens containing UV filters like octisalate helps prevent skin cancer by protecting against UV radiation, which is a known carcinogen 2.
  • Individuals with specific allergies or sensitivities may want to perform patch tests before widespread application, but from a cancer risk perspective, octisalate is considered safe for use in approved products 3.
  • Other sunscreen ingredients, such as oxybenzone and octinoxate, have raised concerns about their potential impact on human health and the environment, but octisalate is not specifically linked to these concerns 4, 5.

Overall, the current scientific evidence supports the safe use of octisalate in sunscreens for cancer prevention, and individuals should follow the recommended usage guidelines and take precautions to minimize any potential risks.

References

Research

Sunscreens and their usefulness: have we made any progress in the last two decades?

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2021

Research

A review of inorganic UV filters zinc oxide and titanium dioxide.

Photodermatology, photoimmunology & photomedicine, 2019

Research

Allergic contact dermatitis from octisalate and cis-3-hexenyl salicylate.

Dermatitis : contact, atopic, occupational, drug, 2006

Research

Update About the Effects of the Sunscreen Ingredients Oxybenzone and Octinoxate on Humans and the Environment.

Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.