What are the diagnostic criteria for Thoracic Outlet Syndrome (TOS)?

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Last updated: February 22, 2025View editorial policy

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Differential Diagnosis for Thoracic Outlet Syndrome

  • Single Most Likely Diagnosis
    • Thoracic outlet syndrome (TOS) itself: This is the most likely diagnosis given the question, as the symptoms and presentation are likely consistent with compression or irritation of the nerves and/or blood vessels in the thoracic outlet.
  • Other Likely Diagnoses
    • Cervical radiculopathy: This condition involves compression or irritation of the nerve roots in the cervical spine, which can cause similar symptoms to TOS, such as pain, numbness, and weakness in the arm.
    • Rotator cuff tendinitis or tear: Shoulder injuries can cause pain and limited mobility that might be confused with TOS symptoms.
    • Brachial plexitis (neuralgic amyotrophy): Inflammation of the brachial plexus can cause severe pain and weakness in the shoulder and arm, mimicking some TOS symptoms.
  • Do Not Miss Diagnoses
    • Pulmonary embolism: Although less likely, a pulmonary embolism can cause sudden onset of chest pain and shortness of breath, which might be confused with TOS symptoms, especially if there's associated arm pain.
    • Aortic dissection: This is a life-threatening condition where the inner layer of the aorta tears, causing severe chest pain that can radiate to the back or arm, potentially mimicking TOS.
    • Pancoast tumor: A type of lung cancer located at the top of the lung, which can cause shoulder and arm pain due to invasion of the brachial plexus, mimicking TOS.
  • Rare Diagnoses
    • Arteriovenous malformation (AVM) or other vascular anomalies: Rare vascular abnormalities in the thoracic outlet could cause symptoms similar to TOS due to abnormal blood flow.
    • Tumors compressing the thoracic outlet: Although rare, tumors such as schwannomas or other soft tissue tumors could compress the nerves or vessels in the thoracic outlet, leading to TOS-like symptoms.
    • Raynaud’s phenomenon: A condition that affects blood flow to the fingers and toes, and sometimes the ears, nose, and lips, which could be considered in the differential for vascular TOS.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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