From the Research
Cefoperazone-sulbactam should be dosed at 2 g/2 g twice daily for optimal efficacy in patients with acute bacterial infections, including those with chronic kidney disease, as supported by the most recent and highest quality study 1. The dosage of cefoperazone-sulbactam can vary depending on the severity of the infection and the patient's renal function.
- For most infections, the typical dose is 1-2 grams of cefoperazone component (2-4 grams of the combination) given intravenously every 12 hours.
- For severe infections, the dosage may be increased to 2-4 grams of cefoperazone component every 12 hours.
- The usual adult daily dose should not exceed 8 grams of cefoperazone. Some key points to consider when dosing cefoperazone-sulbactam include:
- Dosage adjustments are necessary for patients with hepatic impairment or renal dysfunction, particularly when creatinine clearance is below 30 ml/min.
- For patients with both hepatic and renal impairment, the maximum daily dose should not exceed 2 grams of cefoperazone.
- Treatment duration typically ranges from 5-14 days depending on the type and severity of infection.
- The drug should be administered by slow IV infusion over 15-30 minutes or deep intramuscular injection. Cefoperazone-sulbactam works by inhibiting bacterial cell wall synthesis (cefoperazone component) while the sulbactam protects against beta-lactamase enzymes that would otherwise inactivate the antibiotic, making it effective against a broader spectrum of bacteria including many resistant strains 2, 3. The optimal dosage of cefoperazone-sulbactam for patients with chronic kidney disease has been investigated in a recent study, which found that a dose of 2 g/2 g twice daily achieved better clinical efficacy than a reduced dosage regimen 1. Additionally, the pharmacokinetics of cefoperazone and sulbactam have been studied in healthy volunteers, and the bioequivalence of different formulations has been established 4. Overall, cefoperazone-sulbactam is an effective and safe antibiotic for the treatment of acute bacterial infections, and its dosage should be adjusted based on the patient's renal function and the severity of the infection.