Differential Diagnosis for Diffuse Hepatic Disease with Fatty Infiltration Grade II
Single Most Likely Diagnosis
- Non-Alcoholic Fatty Liver Disease (NAFLD): This is the most common cause of diffuse hepatic fatty infiltration, often associated with obesity, diabetes, and metabolic syndrome. Grade II fatty infiltration suggests a moderate level of steatosis, which is consistent with NAFLD.
Other Likely Diagnoses
- Alcoholic Liver Disease: Chronic alcohol consumption can lead to fatty liver, and the presence of grade II fatty infiltration could be an early sign of alcoholic liver disease.
- Hepatic Steatosis due to Medications: Certain medications, such as corticosteroids, tamoxifen, and certain antidepressants, can cause fatty liver. A thorough medication history is essential to consider this diagnosis.
- Hepatic Steatosis due to Total Parenteral Nutrition: Patients receiving long-term total parenteral nutrition may develop fatty liver due to the high caloric and lipid content of the nutrition.
Do Not Miss Diagnoses
- Wilson's Disease: Although rare, Wilson's disease is a genetic disorder that can cause fatty liver, and missing this diagnosis can lead to severe liver damage and other systemic complications.
- Alpha-1 Antitrypsin Deficiency: This genetic disorder can cause liver disease, including fatty liver, and is essential to diagnose to provide appropriate management and genetic counseling.
- Acute Fatty Liver of Pregnancy: Although this condition typically occurs in the third trimester of pregnancy, it is crucial to consider in pregnant women presenting with fatty liver to prevent severe maternal and fetal complications.
Rare Diagnoses
- Abetalipoproteinemia: A rare genetic disorder characterized by the inability to absorb dietary fats, leading to fatty liver and other systemic manifestations.
- Lipodystrophy: A group of rare disorders characterized by abnormal fat distribution, which can lead to fatty liver and other metabolic complications.
- Glycogen Storage Diseases: Certain glycogen storage diseases, such as von Gierke's disease, can cause fatty liver due to the accumulation of glycogen and other metabolic abnormalities.