From the Research
Baclofen can be used for extended periods under proper medical supervision, with the treatment duration individualized based on patient response and tolerability, as evidenced by a 2023 Cochrane review 1. The typical starting dose is 5 mg three times daily, gradually increased as needed up to a maximum of 80 mg per day. However, doses and duration should be individualized based on patient response and tolerability. For long-term use, regular check-ups are essential to assess ongoing effectiveness and monitor for side effects. Patients should not abruptly stop taking baclofen, as this can lead to withdrawal symptoms. If discontinuation is needed, the dose should be gradually tapered under medical guidance. Baclofen works by activating GABA-B receptors in the spinal cord, reducing muscle spasticity. While generally well-tolerated, long-term use may carry risks of tolerance or dependence in some patients. Therefore, periodic reevaluation of the need for continued treatment is important to ensure the benefits outweigh any potential risks. Some key points to consider when using baclofen for extended periods include:
- Monitoring for signs of tolerance or dependence, such as increased dosage requirements or withdrawal symptoms when attempting to discontinue the medication 2.
- Regularly assessing the patient's response to treatment and adjusting the dosage as needed to minimize side effects and maximize efficacy.
- Being aware of potential interactions with other medications, such as benzodiazepines, and taking steps to minimize these interactions 3.
- Considering alternative treatment options for patients who experience adverse effects or do not respond to baclofen therapy. It's also important to note that the use of baclofen for alcohol use disorder is considered "off-label" and requires careful medical monitoring due to safety considerations, particularly at higher doses and in patients with comorbid physical and/or psychiatric conditions 2.