From the Research
Vynmat (cariprazine) should be tapered when discontinuing to minimize withdrawal symptoms, as recommended by the most recent clinical practice guidelines on depression, which emphasize the importance of gradual tapering to mitigate withdrawal symptoms 1. A gradual taper over 1-2 weeks is recommended, reducing the dose by approximately 50% every 3-4 days. For example, if taking 3mg daily, reduce to 1.5mg for 3-4 days, then to 0.75mg for 3-4 days before stopping completely. Some key points to consider when tapering Vynmat include:
- Always consult with your prescribing healthcare provider before making any changes to your medication regimen, as individual needs may vary.
- Tapering is important because Vynmat affects dopamine and serotonin receptors in the brain, and sudden discontinuation can lead to rebound symptoms including anxiety, insomnia, irritability, or worsening of the original condition.
- Patients with a history of severe mental illness should be monitored closely during the tapering process.
- If withdrawal symptoms occur during tapering, the reduction can be made more gradually by extending the time between dose reductions or using smaller decrements, as supported by the principles of drug titration 2. The importance of tapering Vynmat is further emphasized by the potential risks associated with sudden discontinuation, including rebound symptoms and worsening of the original condition, which can have a significant impact on morbidity, mortality, and quality of life.