From the FDA Drug Label
Indications and Usage For debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis pilaris, keratosis palmaris, keratoderma, corns and calluses, as well as damaged, ingrown and devitalized nails.
- Keratosis pilaris is a condition that can be treated with urea (TOP), as it is a hyperkeratotic condition.
- The drug is useful for treating keratosis pilaris, among other conditions, as stated in the drug label 1.
From the Research
Keratosis pilaris can be effectively managed with gentle exfoliation and moisturization, and for more severe cases, laser therapy, particularly Nd:YAG laser, has shown promising results. To manage this condition, use gentle exfoliation with a washcloth or mild chemical exfoliants containing salicylic acid, lactic acid, or glycolic acid 2, 3. Apply moisturizers with urea, lactic acid, or ammonium lactate (like AmLactin or CeraVe SA) daily after showering when skin is still damp. For more severe cases, prescription retinoids such as tretinoin 0.025% cream may help 4. Avoid hot showers, harsh soaps, and excessive scrubbing as these can worsen dryness. Maintain consistent hydration by drinking plenty of water and using a humidifier in dry environments.
Key Considerations
- Keratosis pilaris is a common, harmless skin condition that causes small, rough bumps typically on the upper arms, thighs, cheeks, or buttocks 5.
- The condition often improves in summer months and may resolve on its own with age.
- The bumps occur when keratin, a protein in skin, builds up and blocks hair follicles, though the exact cause is unknown.
- Genetic factors play a role, and it's more common in people with dry skin or certain conditions like eczema or ichthyosis 5, 6.
- Laser therapy, particularly Nd:YAG laser, has shown promising results in treating keratosis pilaris, with a relatively favorable side-effect profile 3.
Treatment Options
- Gentle exfoliation with a washcloth or mild chemical exfoliants containing salicylic acid, lactic acid, or glycolic acid.
- Moisturizers with urea, lactic acid, or ammonium lactate (like AmLactin or CeraVe SA) applied daily after showering when skin is still damp.
- Prescription retinoids such as tretinoin 0.025% cream for more severe cases.
- Laser therapy, particularly Nd:YAG laser, for severe cases or when other treatments are ineffective 2, 3.