Inflammatory Bowel Disease (IBD): Night sweats can be associated with active inflammation in IBD, such as Crohn's disease or ulcerative colitis. The presence of GI discomfort and an elevated CRP level supports this diagnosis, as both are common findings in IBD.

Gastroesophageal Reflux Disease (GERD): While GERD is primarily associated with heartburn and regurgitation, some patients may experience night sweats due to discomfort or pain. The elevated CRP could be related to inflammation in the esophagus.
Peptic Ulcer Disease: Similar to GERD, peptic ulcers can cause GI discomfort and potentially night sweats. The elevated CRP may indicate an active inflammatory process.
Diverticulitis: This condition involves inflammation of the diverticula in the colon and can cause GI discomfort, night sweats, and an elevated CRP level.

Lymphoma: Although less common, lymphoma can present with night sweats, GI discomfort (if the GI tract is involved), and an elevated CRP level due to inflammation and tumor activity. Missing this diagnosis could be fatal.
Tuberculosis: TB can cause night sweats, GI symptoms if the GI tract is involved, and an elevated CRP. It's crucial not to miss this diagnosis due to its potential severity and the need for specific treatment.
Endocarditis: Infective endocarditis can present with non-specific symptoms including night sweats and elevated CRP. Although GI discomfort is not a primary symptom, systemic infection can cause a wide range of symptoms.

Whipple's Disease: A rare, systemic bacterial infection that can cause malabsorption, weight loss, and a variety of other symptoms including night sweats and GI discomfort.
Eosinophilic Gastroenteritis: A rare condition characterized by eosinophilic infiltration of the GI tract, leading to inflammation, which could potentially cause the symptoms described.
Carcinoid Syndrome: Although typically associated with flushing and diarrhea, carcinoid syndrome can occasionally present with night sweats due to the systemic effects of the tumor's secretions.