Differential Diagnosis for Parotitis Swelling with Supraclavicular Swelling
Single Most Likely Diagnosis
- Tuberculosis: This is a common cause of parotitis, especially in endemic areas, and can also cause supraclavicular lymphadenopathy due to the spread of the infection.
Other Likely Diagnoses
- Sjögren's Syndrome: An autoimmune disorder that can cause parotid gland swelling and may also be associated with lymphadenopathy, including supraclavicular nodes.
- Sarcoidosis: A systemic granulomatous disease that can affect the parotid glands and cause lymphadenopathy, including in the supraclavicular region.
- Lymphoma: Both Hodgkin's and non-Hodgkin's lymphoma can present with lymphadenopathy, including supraclavicular nodes, and may also involve the parotid gland.
Do Not Miss Diagnoses
- Metastatic Malignancy: It is crucial not to miss the possibility of a metastatic malignancy, such as lung, breast, or gastrointestinal cancer, which can cause both parotid gland swelling (due to direct invasion or metastasis) and supraclavicular lymphadenopathy.
- HIV/AIDS: Infection with HIV can lead to parotid gland swelling and lymphadenopathy, including in the supraclavicular region, due to the disease itself or opportunistic infections.
Rare Diagnoses
- Heerfordt's Syndrome: A rare form of sarcoidosis that specifically affects the parotid gland, uvea, facial nerve, and sometimes the central nervous system, and can cause supraclavicular lymphadenopathy.
- Kimura Disease: A rare, chronic inflammatory disorder that primarily affects the head and neck region, including the parotid gland, and can cause lymphadenopathy, including in the supraclavicular area.
- Castleman Disease: A rare lymphoproliferative disorder that can cause lymphadenopathy, including in the supraclavicular region, and may also involve the parotid gland.