From the Research
Estradiol and Estratest are unlikely to cause significant weight gain in patients undergoing Hormone Replacement Therapy (HRT), with most patients experiencing minimal or no weight change. Weight changes during HRT are typically modest, with most patients experiencing either minimal weight gain (2-5 pounds) or no change at all. Estradiol, a form of estrogen, may contribute to fluid retention and increased fat deposition, particularly in the hips and thighs, but recent studies suggest that it may also have a protective effect against obesity and insulin resistance 1. Estratest, which combines estrogen with testosterone, might actually help counteract some weight gain effects since testosterone can promote lean muscle mass. Some key points to consider:
- The effects of HRT on weight vary significantly between individuals, and many factors beyond hormones influence weight during HRT, including age-related metabolic changes, diet, exercise habits, and other medications 2.
- To minimize potential weight gain, patients should maintain regular physical activity (both cardiovascular exercise and strength training), follow a balanced diet, monitor sodium intake to reduce fluid retention, and have regular follow-up appointments with their healthcare provider to adjust hormone dosages if needed.
- Weight changes should be discussed with your healthcare provider but are rarely a reason to discontinue necessary hormone therapy if the benefits outweigh this side effect, as HRT can have numerous benefits for menopausal symptoms, bone health, and cardiovascular disease prevention 3, 2.
- Recent studies have highlighted the importance of considering the timing of HRT initiation, type and route of administration, and patient-specific considerations when prescribing HRT 2. It's essential to note that the most recent and highest quality study on this topic, published in 2022, provides guidance on the current recommendations for HRT use in menopausal women, emphasizing the benefits and potential risks associated with HRT 3.