From the Guidelines
The dose of Augmentin (Amoxicillin/Clavulanate) is 500 mg/125 mg three times daily, 875 mg/125 mg twice daily, or 2,000 mg/125 mg twice daily.
Dosage Information
- The recommended dosage for outpatient adults with comorbidities is amoxicillin/clavulanate 500 mg/125 mg three times daily, or amoxicillin/clavulanate 875 mg/125 mg twice daily, or 2,000 mg/125 mg twice daily 1.
- A study comparing the efficacy and safety of oral pharmacokinetically enhanced amoxicillin-clavulanate (2000/125 mg) vs. those of amoxicillin-clavulanate (875/125 mg) found that both regimens were effective in the treatment of bacterial community-acquired pneumonia in adults 1.
- Another study found that a new formulation of amoxicillin/clavulanate (2 g/125 mg) eradicated amoxicillin-resistant strains (MICs, 4–8 mg/L) in two randomized controlled trials 1.
Important Considerations
- The choice of dosage may depend on the severity of the infection, the presence of comorbidities, and the susceptibility of the causative organism to amoxicillin/clavulanate.
- It is essential to note that the prevalence of resistance to amoxicillin/clavulanate may vary depending on the region and the specific population being treated.
- The use of amoxicillin/clavulanate should be guided by local resistance patterns and susceptibility testing whenever possible 1.
The FDA Drug Labels for amoxicillin (PO) do not address this question.
From the Research
Dosing Information for Augmentin (Amoxicillin/Clavulanate)
The dosing of Augmentin (Amoxicillin/Clavulanate) can vary based on the specific formulation and the condition being treated. Key points regarding dosing include:
- For adult respiratory tract infections due to drug-resistant pathogens, a pharmacokinetically enhanced tablet dosage form of amoxicillin/clavulanate 2000/125 mg twice daily (available as Augmentin XR in the USA) has been developed 2.
- For pediatric use in persistent or recurrent acute otitis media, amoxicillin/clavulanate 90/6.4 mg/kg/day in two divided doses (Augmentin ES-600) is recommended 2.
- A dose of 375 mg tds of Augmentin is mentioned for the treatment of urinary tract infections 3.
- Twice daily formulations of amoxicillin/clavulanate have been developed, with the amount of amoxicillin increased relative to clavulanate to provide equivalent bacteriological and clinical efficacy 4.
- For infections in infants and children, high dose amoxicillin/clavulanate (Augmentin ES-600) provides a 14:1 ratio of amoxicillin to clavulanate, with 600 mg of amoxicillin per 5 ml 5.
- Amoxicillin/clavulanic acid 2000 mg/125 mg extended release (Augmentin XR) is designed for adults and adolescents to provide more effective therapy against community-acquired respiratory tract pathogens 6.
Formulations and Their Uses
Different formulations of Augmentin are used for various conditions:
- Augmentin XR is used for adult respiratory tract infections due to drug-resistant pathogens 2, 6.
- Augmentin ES-600 is used for pediatric patients with persistent or recurrent acute otitis media 2, 5.
- Standard formulations of Augmentin are used for a range of community-acquired infections, including urinary tract infections 3 and respiratory tract infections 4.