From the Research
For acute bacterial prostatitis, Bactrim (trimethoprim/sulfamethoxazole) is typically prescribed at a dose of one double-strength tablet (160 mg trimethoprim/800 mg sulfamethoxazole) twice daily for 14 days, while for chronic bacterial prostatitis, the same dosage is recommended but for a longer duration of 4-12 weeks, as supported by the most recent study 1. The treatment of prostatitis with Bactrim is based on its ability to concentrate in prostatic fluid and its effectiveness against common urinary pathogens, particularly gram-negative bacteria like E. coli, which cause most cases of bacterial prostatitis 2, 3. Some key points to consider when prescribing Bactrim for prostatitis include:
- Patients should take Bactrim with a full glass of water and may take it with food if stomach upset occurs.
- It's essential to complete the entire prescribed course even if symptoms improve before finishing the medication.
- Common side effects include rash, nausea, and photosensitivity, so sun protection is advised.
- Patients should maintain adequate hydration while taking this medication to prevent crystalluria. The effectiveness of Bactrim in treating prostatitis has been studied in various trials, with some showing cure rates of around 40% for chronic bacterial prostatitis 2, while others have reported higher success rates with longer treatment durations 4, 5. However, the most recent and highest quality study 1 provides the most reliable guidance on the recommended dose and treatment duration for Bactrim in prostatitis.