From the FDA Drug Label
Mixed Agonist/Antagonist Opioid Analgesics Clinical Impact:May reduce the analgesic effect of oxycodone hydrochloride tablets and/or may precipitate withdrawal symptoms Intervention:Avoid concomitant use Examples:Butorphanol, nalbuphine, pentazocine, buprenorphine
Concomitant use of buprenorphine and oxycodone is not recommended. The use of buprenorphine, a mixed agonist/antagonist opioid analgesic, with oxycodone may reduce the analgesic effect of oxycodone and/or precipitate withdrawal symptoms. It is advised to avoid concomitant use of these medications 1.
From the Research
No, it is not safe to take buprenorphine (Subutex) and oxycodone (OxyContin) at the same time due to potentially dangerous drug interactions and increased risk of severe respiratory depression, which can be life-threatening. Buprenorphine is a partial opioid agonist that binds strongly to opioid receptors, while oxycodone is a full opioid agonist. When taken together, buprenorphine can block the effects of oxycodone, potentially leading to reduced pain control. More importantly, this combination increases the risk of severe respiratory depression, which can be life-threatening. Additionally, taking these medications together can precipitate withdrawal symptoms in individuals who are physically dependent on opioids.
According to a recent study published in 2024 2, all opioids have a risk of causing respiratory depression and reduced cerebral circulation, and the combination of opioids can increase this risk. Another study published in 2021 3 found that atypical opioids, such as buprenorphine, may be safer than conventional opioids, but the combination of opioids can still increase the risk of respiratory depression.
If you are currently prescribed one of these medications and are experiencing pain or opioid use disorder that requires treatment, consult with your healthcare provider about appropriate medication options. Never adjust your medication regimen without medical supervision, especially with opioid medications. The risks associated with combining buprenorphine and oxycodone are supported by multiple studies, including one published in 2020 4 that found the combined use of opioids and benzodiazepines increases the risk for potentially lethal respiratory depression.
Key points to consider:
- Buprenorphine and oxycodone should not be taken together due to increased risk of respiratory depression
- Combination of opioids can increase the risk of severe respiratory depression, which can be life-threatening
- Consult with a healthcare provider before adjusting medication regimen, especially with opioid medications
- Atypical opioids, such as buprenorphine, may be safer than conventional opioids, but combination with other opioids can still increase risk of respiratory depression.