What is the efficacy of magnesium glycinate for pain management?

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Last updated: February 23, 2025View editorial policy

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From the Research

Magnesium glycinate is a potentially effective treatment for pain management, particularly for conditions like fibromyalgia, migraines, and muscle soreness, as evidenced by the most recent and highest quality study available 1. The study by 1 found that a 2-week intravenous magnesium infusion followed by 4 weeks of oral magnesium supplementation can reduce pain intensity and improve lumbar spine mobility during a 6-month period in patients with refractory chronic low back pain with a neuropathic component. Key points to consider when using magnesium glycinate for pain management include:

  • Starting with a lower dose and increasing gradually to avoid digestive side effects
  • Combining magnesium glycinate with other pain management strategies like gentle exercise, proper sleep, and stress reduction techniques
  • Being aware of potential interactions with certain medications, such as antibiotics and blood pressure medications
  • Consulting a healthcare provider before starting magnesium supplementation, especially if you have kidney problems or take certain medications It's also important to note that while magnesium glycinate may have a positive effect on pain management, the evidence is not yet conclusive, and more research is needed to fully understand its effects 2. Additionally, other studies have explored the use of glycine and magnesium in pain management, including the use of intrathecal glycine for pain and dystonia in complex regional pain syndrome 3, and the role of glycine transport inhibitors in the treatment of pain 4. However, the study by 1 provides the most recent and highest quality evidence available, and its findings should be prioritized when making treatment decisions.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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