From the Guidelines
Tazact (piperacillin-tazobactam) should be dosed at 4.5g (4g piperacillin/0.5g tazobactam) every 6-8 hours for moderate to severe infections in adults with normal renal function, with dosage adjustments necessary for impaired renal function, as evidenced by recent guidelines 1.
Dosage and Administration
For patients with impaired renal function, the following dosage adjustments are recommended:
- For CrCl 20-40 mL/min, the recommended dose is 4.5g every 8 hours;
- For CrCl <20 mL/min, 4.5g every 12 hours is appropriate;
- Patients on hemodialysis should receive 2.25g every 8 hours with an additional 0.75g after each dialysis session.
Treatment Duration and Monitoring
Treatment duration typically ranges from 7-14 days depending on infection severity and site. The medication should be administered as an intravenous infusion over 30 minutes. Renal function should be monitored throughout treatment, with dosage adjustments made as needed.
Mechanism of Action
Piperacillin-tazobactam works by inhibiting bacterial cell wall synthesis (piperacillin) while tazobactam protects piperacillin from beta-lactamase enzymes that would otherwise inactivate it, making it effective against many resistant organisms.
Recent Guidelines
Recent guidelines from the Journal of Microbiology, Immunology and Infection 1 support the use of piperacillin-tazobactam for the treatment of infections due to multidrug-resistant organisms, with recommended dosages and administration guidelines provided. Additionally, studies have shown that continuous or prolonged infusion of beta-lactam antibiotics, including piperacillin-tazobactam, may improve clinical outcomes in critically ill patients 1.
From the FDA Drug Label
2.4 Dosage in Adult Patients with Renal Impairment
Dosage adjustment is recommended for patients with renal impairment. The recommended dosage is:
- CrCl ≥ 40 mL/min: usual recommended dosage
- CrCl 20-40 mL/min: 2.25 g every 6 hours
- CrCl < 20 mL/min: 2.25 g every 8 hours
Note: All dosing recommendations are based on the piperacillin component of piperacillin and tazobactam for injection.
The dosage and usage of Tazact (piperacillin and tazobactam) for treating moderate to severe infections, particularly in cases with impaired renal function, is as follows:
- For patients with CrCl ≥ 40 mL/min, the usual recommended dosage is given.
- For patients with CrCl 20-40 mL/min, the recommended dosage is 2.25 g every 6 hours.
- For patients with CrCl < 20 mL/min, the recommended dosage is 2.25 g every 8 hours. Key points to consider:
- Dosage adjustment is necessary for patients with renal impairment.
- The recommended dosage is based on the piperacillin component of piperacillin and tazobactam for injection.
- Patients with impaired renal function require careful monitoring and dosage adjustment to minimize the risk of adverse reactions 2.
From the Research
Tazact Coverage of Bacteria
- Tazact, a combination of piperacillin and tazobactam, has a broad spectrum of antibacterial activity against most Gram-positive and Gram-negative aerobic bacteria and anaerobic bacteria, including many pathogens producing beta-lactamases 3, 4, 5.
- The combination is effective against a wide range of bacteria, including staphylococci, streptococci, and many gram-negative aerobic and anaerobic bacteria 5.
- Tazact has been shown to be effective in the treatment of various infections, including:
Dosage and Usage
- The dosage and usage of Tazact may vary depending on the specific infection being treated and the patient's renal function 3, 4.
- In patients with impaired renal function, the dosage of Tazact may need to be adjusted to avoid accumulation of the drug and its metabolites 3, 4.
- Tazact can be administered in combination with other antibiotics, such as aminoglycosides, to enhance its effectiveness against certain types of bacteria 3, 4.