Differential Diagnosis for 55-year-old Female with Weight Loss, Vaginal Bleeding, and Abdominal Fullness
- Single most likely diagnosis
- Ovarian Cancer: This is a common diagnosis in postmenopausal women presenting with abdominal fullness, weight loss, and vaginal bleeding. The symptoms are classic for advanced ovarian cancer, which often presents with non-specific symptoms until late in the disease.
- Other Likely diagnoses
- Endometrial Cancer: This is another common gynecologic malignancy that can present with vaginal bleeding and weight loss. Abdominal fullness can occur if the cancer has spread to the abdomen.
- Uterine Sarcoma: Although less common than endometrial cancer, uterine sarcomas can present with similar symptoms, including vaginal bleeding and abdominal fullness.
- Cervical Cancer: While less likely in a 55-year-old woman due to screening, cervical cancer can present with vaginal bleeding and abdominal symptoms if advanced.
- Do Not Miss diagnoses
- Ectopic Pregnancy: Although unlikely in a 55-year-old woman, an ectopic pregnancy can present with vaginal bleeding and abdominal symptoms. Given the potential for severe consequences if missed, it must be considered.
- Uterine Leiomyosarcoma (malignant uterine fibroid): This rare tumor can cause rapid uterine enlargement, leading to abdominal fullness and potentially vaginal bleeding.
- Metastatic Cancer to the Ovary or Uterus: Cancers from other primary sites (e.g., breast, colon) can metastasize to the ovaries or uterus, presenting with similar symptoms.
- Rare diagnoses
- Lymphoma involving the uterus or ovaries: This can cause abdominal fullness and systemic symptoms like weight loss but is less common.
- Germ Cell Tumors of the Ovary: These are rare ovarian tumors that can present with abdominal fullness and systemic symptoms but are more common in younger women.
- Sex Cord-Stromal Tumors of the Ovary: These are rare ovarian tumors that can produce hormones, leading to vaginal bleeding, and can cause abdominal fullness due to tumor growth.