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Last updated: June 2, 2025View editorial policy

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Differential Diagnosis for Knee Lump

  • Single most likely diagnosis
    • Prepatellar bursitis: This condition, also known as housemaid's knee, is characterized by swelling and inflammation of the bursa in front of the kneecap (patella). The patient's description of a lump on the knee with onset on 5/29 and 4/10 pain is consistent with this diagnosis. The absence of warmth, fever, and normal skin color also supports this diagnosis.
  • Other Likely diagnoses
    • Osteochondroma: A benign bone tumor that can cause a lump on the knee. Although it's a possible cause, the acute onset on 5/29 makes it less likely.
    • Ganglion cyst: A non-cancerous lump that can occur on the knee, often associated with a joint or tendon. The patient's symptoms could be consistent with a ganglion cyst.
    • Lipoma: A benign fatty tumor that can cause a lump on the knee. The description of the lump as a "1/2 egg" size is consistent with a lipoma.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed)
    • Septic arthritis: Although the patient denies fever and the skin is not warm to touch, septic arthritis is a medical emergency that requires prompt attention. If left untreated, it can lead to serious complications, including joint destruction and systemic infection.
    • Soft tissue sarcoma: A rare but aggressive type of cancer that can cause a lump on the knee. Although unlikely, it's essential to consider this diagnosis to ensure prompt treatment if necessary.
  • Rare diagnoses
    • Synovial chondromatosis: A rare condition characterized by the growth of cartilage in the joint, which can cause a lump on the knee.
    • Pigmented villonodular synovitis (PVNS): A rare condition that causes inflammation and overgrowth of the joint lining, leading to a lump on the knee.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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