From the FDA Drug Label
DOSAGE AND ADMINISTRATION Otitis Externa The recommended dosage regimen for the treatment of otitis externa is: For pediatric patients (from 6 months to 13 years old): Five drops (0.25 mL, 0.75 mg ofloxacin) instilled into the affected ear once daily for seven days. For patients 13 years and older: Ten drops (0.5 mL, 1. 5 mg ofloxacin) instilled into the affected ear once daily for seven days.
Il farmaco ofloxacin è disponibile in Italia come gocce otiche. Le dosi raccomandate sono:
- Per i pazienti pediatrici (da 6 mesi a 13 anni): 5 gocce (0,25 mL, 0,75 mg di ofloxacin) instillate nell'orecchio affetto una volta al giorno per sette giorni.
- Per i pazienti di età superiore ai 13 anni: 10 gocce (0,5 mL, 1,5 mg di ofloxacin) instillate nell'orecchio affetto una volta al giorno per sette giorni 1.
From the Research
In Italy, the equivalent of ofloxacin otic drops is typically available as Exocin Otic (ofloxacin 0.3%) with a standard dosage of 5 drops instilled into the affected ear(s) twice daily for 7 days for most ear infections.
Dosage and Administration
For severe infections, treatment may extend to 14 days. For children, the same concentration and dosing applies, but the volume may be adjusted based on age. When administering, tilt the head with the affected ear upward, instill the drops, and remain in this position for 5 minutes to ensure proper distribution.
Mechanism of Action
The medication works by inhibiting bacterial DNA gyrase, preventing bacterial DNA replication and effectively treating common ear infections caused by susceptible organisms, as shown in studies such as 2.
Follow-up and Completion of Treatment
If symptoms persist beyond the treatment period, follow-up with a healthcare provider is recommended. Patients should complete the full course of treatment even if symptoms improve before completion.
Key Points to Consider
- The effectiveness of ofloxacin otic solution has been demonstrated in various studies, including 3, 4, and 5, which compared its efficacy to other treatments for ear infections.
- Ofloxacin otic solution has been shown to be safe and effective in both children and adults, with a low risk of adverse events, as reported in 2 and 6.
- The medication is available in Italy as Exocin Otic, with a standard dosage of 5 drops twice daily for 7 days, which can be adjusted based on the severity of the infection and the patient's age.