From the Research
For a patient experiencing potential zinc toxicity from denture adhesive, immediate discontinuation of the zinc-containing adhesive is the first critical step, as supported by the most recent study 1. The patient should switch to a zinc-free alternative adhesive product. Medical evaluation is essential, including blood tests to measure serum zinc levels, copper levels (as zinc toxicity often causes copper deficiency), and complete blood count to assess for anemia. Treatment typically involves copper supplementation, usually 2-4 mg of elemental copper daily for several months, as zinc excess interferes with copper absorption, as noted in 2. In severe cases with neurological symptoms like numbness, weakness, or difficulty walking, hospitalization may be necessary for intravenous copper administration and supportive care, highlighting the importance of early recognition and intervention 3. Nutritional assessment and supplementation of other depleted nutrients may also be required. Recovery can take months as excess zinc is slowly eliminated from the body. The toxicity occurs because zinc in adhesives can be absorbed systemically when used excessively or for prolonged periods, creating an imbalance in trace minerals that can lead to neurological damage, blood disorders, and other systemic effects, as discussed in 4 and 5. Key considerations include:
- Discontinuation of zinc-containing adhesive
- Switch to zinc-free alternative
- Medical evaluation for zinc and copper levels, and anemia
- Copper supplementation
- Potential hospitalization for severe cases
- Nutritional assessment and supplementation
- Awareness of the risks of zinc toxicity and copper deficiency, especially in patients using zinc-containing denture adhesives, as emphasized in 1.