From the Guidelines
The maximum recommended dose of Trimix for erectile dysfunction is up to 50 units, with most men responding to doses between 10-30 units. Trimix dosing typically starts at a low dose of 5-10 units (0.05-0.1 mL) and is gradually adjusted based on individual response 1. The medication is administered via intracavernosal injection directly into the side of the penis using a small insulin syringe. Some key points to consider when using Trimix include:
- Starting with the lowest effective dose and increasing gradually under medical supervision to minimize the risk of priapism (prolonged erection) 1
- Not using Trimix more than 2-3 times per week with at least 24 hours between doses to prevent penile tissue damage
- Potential side effects, including pain at the injection site, bruising, and rarely priapism
- The importance of proper injection technique, with patients receiving thorough training from a healthcare provider before self-administering Trimix works by combining three medications (alprostadil, papaverine, and phentolamine) that relax smooth muscle tissue and increase blood flow to the penis through different complementary mechanisms, making it effective for many men who don't respond to oral medications.
From the Research
Trimix Dosage for Erectile Dysfunction
The recommended dose of Trimix, a mixture of alprostadil, papaverine, and phentolamine, for erectile dysfunction is not explicitly stated in the provided studies. However, the following information can be gathered:
- A study published in 2005 2 investigated the effects of varying doses of Trimix ingredients on penile hemodynamic response. The study used different doses of phentolamine (1 mg), papaverine (5,10, or 20 mg), and alprostadil (2.5, or 10 microg).
- The study found that even at the smallest dose of Trimix ingredients, there were no significant differences in hemodynamic effects, rigidity, pain, and self-satisfaction between Trimix and prostaglandin E1.
- Another study published in 2011 3 reviewed the effectiveness and safety of various interventions for erectile dysfunction, including Trimix. However, the study does not provide specific dosage recommendations for Trimix.
- A study published in 1998 4 investigated the use of oral alpha-blockers in combination with intracavernosal injection therapy for erectile dysfunction. The study used a combination of phentolamine and papaverine, but does not provide information on the maximum human dose of Trimix.
Key Findings
- The maximum human dose of Trimix is not explicitly stated in the provided studies.
- Trimix is a mixture of alprostadil, papaverine, and phentolamine, and the dosage of each ingredient can vary.
- The effectiveness and safety of Trimix for erectile dysfunction have been investigated in several studies, but specific dosage recommendations are not provided.
- The use of Trimix for erectile dysfunction doesn't have a clear maximum dose established by the provided studies, more research is needed to determine the optimal dosage.