What is the recommended dosage of Colace (docusate) for colonoscopy preparation?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 2, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the FDA Drug Label

Directions Take only by mouth. Doses may be taken as a single daily dose or in divided doses. adults and children 12 years and overtake 1-3 capsules daily The FDA drug label does not answer the question.

From the Research

For colonoscopy preparation, Colace (docusate sodium) is not typically recommended as a primary preparation method, and its use should be avoided due to lack of evidence supporting its efficacy in bowel cleansing 1. Instead, the standard colonoscopy preparation usually involves stronger laxatives such as polyethylene glycol solutions (GoLYTELY, MoviPrep), sodium phosphate solutions, or magnesium citrate. These medications more effectively clear the colon of solid matter to allow proper visualization during the procedure. Colace is a stool softener that works by increasing water absorption in the stool, making it easier to pass, but it doesn't have the powerful cleansing effect needed for colonoscopy preparation. Some key points to consider when preparing for a colonoscopy include:

  • Following specific preparation instructions provided by your gastroenterologist
  • Dietary restrictions, such as clear liquids the day before
  • Use of stronger laxatives
  • Adequate hydration Using only Colace would likely result in inadequate bowel cleansing and could lead to a poor-quality examination or the need to reschedule the procedure. Recent studies have shown that docusate is not effective in managing constipation, and its use should be reassessed in the older adult population 1. In addition, studies have compared the efficacy of docusate with other laxatives, such as sennosides, and found that docusate is less effective in inducing laxation 2, 3. Therefore, it is recommended to follow the standard colonoscopy preparation guidelines and avoid using Colace as a primary preparation method.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.