From the Research
Naltrexone and Xanax (alprazolam) can be taken together, but it is crucial to do so under close medical supervision due to potential interactions and side effects. The primary concern is that naltrexone, an opioid antagonist, may potentially enhance the sedative effects of benzodiazepines like Xanax, leading to increased drowsiness, dizziness, and impaired coordination 1, 2. Patients taking both medications should avoid driving or operating heavy machinery until they understand how the combination affects them. It's also important to note that naltrexone will not block the effects of Xanax, as it specifically targets opioid receptors, while Xanax works on GABA receptors in the brain. However, if someone has been using opioids alongside Xanax, starting naltrexone could precipitate withdrawal symptoms from the opioids while potentially making the sedative effects of Xanax more pronounced.
Key Considerations
- Alcohol should be strictly avoided when taking this combination, as all three substances affect central nervous system function and could lead to dangerous respiratory depression.
- Patients should always disclose their complete medication history to their healthcare provider, including any history of substance use disorders, before starting either medication.
- The combination of naltrexone and Xanax may require careful dose adjustment and monitoring to minimize side effects and maximize therapeutic benefits.
- Studies have shown that naltrexone can be effective in reducing the reinforcing effects of stimulants, and its combination with alprazolam may have synergistic effects in certain cases 2.
Monitoring and Precautions
- Regular monitoring of vital signs, mood, and cognitive function is essential when taking naltrexone and Xanax together.
- Patients should be aware of the potential for increased sedation, drowsiness, and impaired coordination, and take necessary precautions to ensure their safety.
- Healthcare providers should be vigilant for signs of opioid withdrawal, respiratory depression, or other adverse effects when initiating or adjusting the doses of these medications.
Conclusion is not allowed, so the answer will continue without one, focusing on the information provided and the question asked.
Given the potential risks and benefits, the decision to use naltrexone and Xanax together should be made on a case-by-case basis, taking into account the individual patient's medical history, current medications, and therapeutic goals. As the most recent and highest quality study is from 2019 3, 4, it is essential to consider the findings of these studies when making treatment decisions. However, the specific study that directly addresses the question of using naltrexone with Xanax is not explicitly mentioned in the provided evidence, so the recommendation is based on the general principles of pharmacology and the potential interactions between these medications.