What are the causes of posterior knee pain?

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Last updated: February 23, 2025View editorial policy

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Differential Diagnosis for Posterior Knee Pain

  • Single Most Likely Diagnosis
    • Baker's Cyst: A fluid-filled cyst that causes pain and swelling in the posterior knee, often associated with knee arthritis or injury. This is a common cause of posterior knee pain, especially in older adults.
  • Other Likely Diagnoses
    • Hamstring Strain: A muscle strain in the back of the thigh can cause posterior knee pain, especially with activities that involve bending or straightening the knee.
    • Gastrocnemius Strain: A strain in the calf muscle can also cause pain in the posterior knee, particularly with activities that involve ankle movement.
    • Popliteus Tendinitis: Inflammation of the popliteus tendon, which connects the popliteus muscle to the lateral femur, can cause posterior knee pain, especially with rotational movements.
  • Do Not Miss Diagnoses
    • Deep Vein Thrombosis (DVT): A blood clot in the deep veins of the leg can cause posterior knee pain, swelling, and warmth. This is a medical emergency that requires prompt treatment.
    • Popliteal Artery Aneurysm: A bulge in the popliteal artery can cause posterior knee pain, swelling, and weakness in the leg. This is a rare but potentially life-threatening condition.
    • Tumor or Cyst: A tumor or cyst in the posterior knee, such as a synovial sarcoma or a ganglion cyst, can cause pain and swelling. Although rare, these conditions can be serious and require prompt evaluation.
  • Rare Diagnoses
    • Popliteal Cystic Adventitial Disease: A rare condition characterized by the formation of cysts in the adventitia of the popliteal artery, which can cause posterior knee pain and claudication.
    • Fabella Syndrome: A rare condition where a small bone in the posterior knee, the fabella, causes pain and inflammation due to friction or impingement.
    • Neurogenic Causes: Rarely, posterior knee pain can be caused by neurogenic conditions such as a lumbar radiculopathy or a peripheral neuropathy.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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