From the FDA Drug Label
Haloperidol decanoate, USP is usually administered monthly or every 4 weeks.
The administration frequency for Haloperidol (Haldol) decanoate is monthly or every 4 weeks 1.
From the Research
Haloperidol decanoate (Haldol Decanoate) is typically administered every 4 weeks (28 days). The initial recommended dose is 10-15 times the daily oral dose of haloperidol, given as an intramuscular injection. For example, if a patient takes 10 mg of oral haloperidol daily, their initial decanoate dose would be 100-150 mg every 4 weeks. After the initial dose, subsequent injections are usually given every 4 weeks, with dosage adjustments made based on the patient's response and side effects. The maintenance dose typically ranges from 50-200 mg every 4 weeks, but some patients may require higher doses. It's essential to note that the first few injections may not provide full therapeutic effect, as it takes time for the medication to reach steady-state levels in the body. Therefore, oral haloperidol may need to be continued for several weeks after starting the decanoate form, as suggested by studies such as 2. The long-acting nature of haloperidol decanoate allows for less frequent dosing compared to daily oral medication, which can improve adherence in patients with chronic psychotic disorders. However, regular monitoring for side effects and efficacy is crucial, and dose adjustments should be made gradually due to the medication's long half-life, as seen in studies like 3 and 4. Some key points to consider when administering haloperidol decanoate include:
- The initial dose is usually 10-15 times the daily oral dose of haloperidol
- Subsequent injections are given every 4 weeks
- Dosage adjustments are made based on the patient's response and side effects
- The maintenance dose typically ranges from 50-200 mg every 4 weeks
- Regular monitoring for side effects and efficacy is crucial
- Dose adjustments should be made gradually due to the medication's long half-life, as supported by studies such as 5 and 6.