From the Research
Treatment for zearalanone exposure primarily involves supportive care and removal from the source of exposure, as there is no specific antidote. The most recent and highest quality study on this topic is from 2022 1, which highlights the importance of understanding the toxicological effects of zearalenone on human health. Initial management should focus on decontamination by removing contaminated clothing and washing exposed skin with soap and water. For ingestion cases, activated charcoal may be administered within 1-2 hours of exposure to reduce absorption.
Supportive measures include:
- Maintaining fluid balance
- Monitoring liver function
- Addressing specific symptoms as they arise Since zearalanone is an estrogenic mycotoxin that can disrupt endocrine function, patients should be monitored for hormonal disturbances, particularly in reproductive systems, as suggested by a study from 2019 2. Long-term follow-up may be necessary to assess potential delayed effects, especially in cases of chronic exposure.
Prevention remains crucial, involving:
- Proper food storage
- Avoiding moldy grains and cereals
- Implementing agricultural practices that minimize fungal contamination Healthcare providers should also consider consulting with poison control centers or toxicologists for guidance on managing significant exposures, as treatment approaches may need to be tailored to the severity and duration of exposure, as noted in a review from 2020 3. Additionally, a study from 2016 4 emphasizes the importance of monitoring zearalenone concentrations in food to minimize its potential effects on human health.