From the Research
Estrogen plus medroxyprogesterone is not recommended or effective for weight loss in perimenopausal women. This hormone therapy combination is primarily used to manage menopausal symptoms like hot flashes and to prevent osteoporosis, not for weight management. In fact, some women may experience weight gain as a side effect of hormone therapy, particularly with medroxyprogesterone 1, 2. For perimenopausal women concerned about weight gain, evidence-based approaches include:
- Regular physical activity (150 minutes of moderate exercise weekly)
- A balanced diet rich in fruits, vegetables, and lean proteins
- Adequate sleep (7-8 hours nightly)
- Stress management techniques These lifestyle modifications are more effective and safer for weight management during perimenopause. The weight changes during perimenopause are complex and related to hormonal fluctuations, decreased muscle mass, and metabolic changes, which hormone therapy does not specifically address 3, 4. If weight gain is significant or concerning, consulting with a healthcare provider about appropriate weight management strategies is recommended rather than using hormone therapy for this purpose. The duration of hormone therapy should be individualized and based on the treatment of menopausal symptoms, rather than weight loss, and should be guided by the healthcare provider's assessment of the benefits and risks of therapy 5, 4.